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Most studies suggest that beta-amyloid buildup is favored least by APOE2 , a bit more by APOE3 , and much more by APOE4 (Belloy et al., 2019)

61,62 One of the major limitations of this study was the low number of patients and the absence of a placebo arm, prompting a placebo-controlled AST-120 Used to Treat Mild Hepatic Encephalopathy (ASTUTE) clinical trial, 63 a multicenter, double-blind RCT that randomized 148 patients with compensated cirrhosis to receive either dose-ranging oral AST-120 (2 or 4 g three times per day) vs