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S-acetyl glutathione is typically dosed lower (100-300 mg) than reduced glutathione because of its theoretically better absorption, though head-to-head clinical comparisons with other forms are limited

The best results come from consistent treatmentsusually once or twice a week for 8-12 weeks, then maintenance treatments monthly

10.1016/j.arr.2023.101936 46 WanX.GargN

Members of the oligopeptide transporters (OPTs) might be responsible for transport of glutathione and its derivates across the plasma membrane, however the opt1-3 and opt6 mutants tested in our study did not exhibit any phenotype difference to WT when exposed to AITC