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This follows its role as a cytoprotection mediator transmitting the mucosal integrity maintenance to other organs therapy [1,2,3,4,5,6,7,8,9,10,11,15,27,28,29,30,33,109,124,125] in consideration of the regular dietary taking (dietary nitrate as an important source of NO in mammals [252]), and nitrate-nitrite-NO pathway (and swallowed nitrite) resulting with high NO concentration in the stomach [253]

Glucagon-like peptide 1 (GLP-1) based therapies have seen a meteoric rise in popularity (about 300% 1 increased use between 2018-2023)