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This would be of special value for patients undergoing several week long radiotherapy during which prolonged fasting is no option

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Interestingly, in breast cancer, the combination of IL-15 and radiation has been recently demonstrated to enhance response to radiation, improve survival and enhance CD8+ T cell infiltration (77), suggesting that this metformin-mediated increase in IL-15 secretion may in part mediate the radiosensitising effect of metformin