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Biochemical dysfunction discussed here include mitochondrial dysfunction [62,63,64] (such as adenosine triphosphate (ATP) production) [37, 65,66,67,68,69], impaired biochemical pathways (the kynurenine pathway [70,71,72,73] and the itaconate shunt [74,75,76,77]), chemical composition of cells (Raman spectroscopy [33, 58, 78] and metabolomic analysis [79,80,81]), and the production of cytokines [47,48,49]

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