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The Endocrine Society's 2024 clinical practice guideline on pharmacological management of obesity recommends anti-obesity medications as an adjunct to lifestyle modification for patients with BMI of 30 or greater, or 27 or greater with comorbidities

As a consequence, although clinical application of PAC may be considered as safe, in the case of severely depleted GSH levels PAC should be administered with caution, especially in subjects with severe GSH depletion who, again, are those at higher risk of developing severe COVID-19 disease

Moreover, it addresses the management of missed doses and potential drug interactions

The Phase 2 readout already signaled that retatrutide was operating in a different category, mean weight loss in the 24% range at the highest dose, a number that until recently was the exclusive territory of bariatric surgery