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200 Consequently, numerous preclinical and clinical efforts have targeted pathways through small-molecule inhibitors of Notch (e.g., -secretase inhibitors), Hedgehog (e.g., Smoothened (SMO) inhibitors), and PI3K/AKT/mTOR (e.g., rapamycin analogs, pan-PI3K inhibitors) to deplete CSC populations

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They are ran by a licensed pharmacist in a state-licensed pharmacy, or federal facility, or by a physician, as well as compounding by or under the direct supervision of a licensed pharmacist in an outsourcing facility