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1 Introduction Autoimmune diseases (ADs) arise from the immune systems aberrant response against self-tissues, encompassing diverse conditions such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel disease (IBD), type 1 diabetes (T1D), and primary biliary cholangitis (PBC) ( Mounting evidence suggests that gut microbiota and its metabolites play a key role in host health and diverse diseases, such as obesity, depression, sclerosis, kidney disease, and dialysis ( At present, in the interest of reshaping the disordered intestinal immune activity in the disease state and alleviating the disease, people propose a series of flora-related immunotherapies based on the close interaction between the intestinal immune system and the flora (34)