Luteinizing hormone (LH) and human chorionic gonadotropin (hCG) through LHCGR play their physiological role, which triggers cascades of signals that are essential to ovulation and corpus luteum (CL) development (42)
More surprisingly, we observed positive gene enrichment in DNA replication fork collapse-responsive genes (RAD51D, SAMHD1, and ZRANB3) 53,54 , oxidative DNA damage repair genes (OGG1, MGMT) 55 , and several antioxidant genes (CAT, GPX7, PRDX3, and SOD2) 56 between day 15 and day 20 of differentiation in BWS hepatocytes (Supplementary Fig
Mitochondrial iron-sulfur cluster dysfunction in neurodegenerative disease
Proposed mechanisms include fibroblast migration and proliferation, modulation of growth-factor signalingincluding EGF and VEGFand changes in reticulin and collagen-fiber formation at injury sites