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In animal experiments, particularly in mouse models, GDF-15 enhances satiety and reduces food intake through its action on the central nervous system

Trial design: 2,339 participants Adults with obesity or overweight + at least one weight-related complication Participants did NOT have diabetes Randomized to placebo or retatrutide 4 mg, 9 mg or 12 mg 80-week double-blind trial Pre-specified extension to 104 weeks in participants with BMI 35 Weight loss results at 80 weeks: 4 mg: -19.0% (~47 lbs / 21.4 kg) 9 mg: -25.9% (~64 lbs / 29.2 kg) 12 mg: -28.3% (~70 lbs / 31.9 kg) That degree of weight loss approaches levels traditionally associated with bariatric surgery

Mounjaro, on the other hand, is a brand-name drug and tends to be more expensive out of pocket

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