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Our data indicate the catalytic Cys256 is needed for the auto-AcT activity, suggesting the lysine side chains must come into close spatial proximity to the active site in order to become acetylated

It showed an antiatherosclerosis effect with animal models and lowered F 2 -isoprostane levels (that are often used as biomarkers for oxidative stress) in vitamin E-deficient mice (Halliwell and Gutteridge, 2015

However, elucidation of the factors that underlie the sensitivity of a given cell type to ferroptosis 7 is crucial to understand the pathophysiological role of ferroptosis and how it may be exploited for the treatment of cancer