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Gastrin secretion in normal subjects and diabetes patients is inhibited by glucagon-like peptide 1: A role in the gastric side effects of glp-1-Derived drugs

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Cyclic peptide structure enhances high-affinity MC4R binding Pharmacophoric regions imitate endogenous -MSH signaling motifs Structural stability improves resistance to enzymatic degradation Moreover, receptor-localization [3] studies demonstrate substantial MC4R expression in hypothalamic regions such as the arcuate nucleus and paraventricular nucleus, both of which play major roles in appetite regulation

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