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Signs Your Semaglutide Dose May Need Adjustment You may benefit from a dose increase if you are experiencing consistent appetite suppression and good tolerability but have plateaued in weekly weight loss after 4 or more weeks at the same dose

12 At present, semaglutide is probably best avoided in patients with significant diabetic retinopathy and liraglutide or dulaglutide are alternatives that have not been associated with worsening of retinopathy