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This decline accelerates oxidative stress, inflammation, and disease risk [2]

Increased intake of folate from food or folic acid from supplements decreases homocysteine concentration in the blood

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Nevertheless, under physiological conditions, in most tissues mitochondria are the major contributors to the cellular ROS production [28,29,30,31], mainly as a side effect of aerobic respiration via oxidative phosphorylation (OXPHOS) occurring on the inner membrane of the mitochondrion [32, 33], but also through other metabolic routes, such as pentose-phosphate pathway and glutathione (GSH) metabolism [34]