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The other thing is that theres a big difference between a person being depressed [versus the GLP-1 side effects], which they have started looking into

Clinical trials conducted in the early 2000s showed modest results, and the compound failed to demonstrate sufficient efficacy to support regulatory approval as a weight-loss medicine

Among studied drugs (Efavirenz, Tenofovir, Emtricitabine, Lamivudine, and Indinavir), only Efavirenz increased ER stress via upregulation and activation of the inositol requiring kinase 1 (IRE1) and protein kinase-like ER kinase (PERK) signaling

As a result, it is difficult to delineate the exact mechanism. Dr