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Additional labeled risks include gallbladder disease, acute kidney injury (particularly with severe gastrointestinal adverse events), and potential worsening of diabetic retinopathy complications with semaglutide

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Clinical studies have shown that GLP-1 medications may help support metabolic health during the menopause transition by improving metabolic stability and supporting blood sugar control

Importantly, while insufficient exercise is a risk factor for many neurodegenerative disorders, excessive cardiovascular exercise (with insufficient recovery) can also lead to numerous adverse health outcomes [216], which may include an increased risk of developing ALS [113]