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High level of the c-Met receptor was confirmed in human melanoma cells M14, M4Beu, A375 and Rel3, and the IC 50 for c-Met inhibitor SU11274 was 45 M [69].Contrary to the expected effect of HGF/c-Met inhibitor, in our experiments with the hypermetastatic and highly tumorigenic variant of human melanoma cell line A375 designated as Rel3 we have shown that SU11274 enriched for the melanoma-initiating cells in vivo

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Reductions in proinflammatory cytokines such as IL-17, IL-23, and TNF- as detected by protein expression levels in immunohistochemistry, alongside histological improvements in epidermal thickness, support this anti-inflammatory mechanism