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These include: lack of awareness among emergency department physicians about proper management of hyperammonemia, strained communication between physicians at primary, secondary, and tertiary hospitals, and shortage of the medications used in the acute management of hyperammonemia

Dysfunctions of MCs can cause pigmentation disorders such as albinism and vitiligo (Coutant et al, 2024), and can lead to malignant transformation into melanoma, an aggressive form of skin cancer responsible for most skin cancer-related deaths (Matthews et al, 2017)