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218 In contrast, an RCT in Norway compared the change in seizure frequency in patients with drug-resistant focal or multifocal epilepsy between 37 patients randomized to 12 weeks of MAD (of whom 28 received the intervention and 24 completed the study) and 38 adults randomized to their habitual diet (of whom 34 received the intervention and 32 completed the study)

This means that roughly 2 - 3% of the population in the United States may now be taking one of these drugs

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Interestingly, a systematic review and meta-analysis of 19 randomized trials reported a reduction of ALT and AST following l-carnitine supplementation