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First, we emulated the two cardiovascular outcome trials SUSTAIN-6 (semaglutide versus placebo) and SURPASS-CVOT (tirzepatide versus dulaglutide) using the RCT-DUPLICATE approach to benchmark findings and inform the study design and analytic approach for expanded questions

(2021, NEJM) reported the dose-response pharmacology that established tirzepatide as a distinct compound from the single-receptor class

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DAG can be utilized in lipid biosynthesis pathways, while the phosphorylated head group may enter signaling pathways or be metabolized further