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Upon Sabs phosphorylation by pJNK on the outside of the outer membrane, SHP1 is released into the intermembrane space where it undergoes activation through phosphorylation by a kinase, perhaps by pSrc
For instance, LDHA has been demonstrated to promote tumor cell survival by mitigating oxidative stress, whereas LDHB deficiency induces mitochondrial dysfunction and oxidative damage, ultimately leading to neurodegeneration in the adult mouse brain (46,47)
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