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Cardiometabolic secondary endpoints, including measures such as waist circumference and blood pressure, were reported directionally in favor of the combination arm

Proteins were detected using the following antibodies: Lyn PerCP (clone C13F9, Cell Signaling Technology), SYK PE (clone B435666, Biolegend), PLC2 AF488 (clone K86-1161, BD Biosciences), pan AKT APC (Miltenyi Biotec), and S6 AF700 (clone 54D2, Cell Signaling Technologies)

Oncogene 34, 57185728

Why cysteine is the rate-limiting factor: The intracellular concentration of cysteine sits close to the Km value of GCL (0.1 to 0.3 mM), meaning the enzyme is operating near its saturation point under normal conditions