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This dual mechanismelevated ghrelin plus declining leptin signalingcreates a powerful biological drive to eat more

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GLP-1 signaling may improve mitochondrial biogenesis via PGC-1a/nuclear respiratory factor-1/mitochondrial transcription factor A signaling regulated by adiponectin/ adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK) 49 and elevates the expression of NAD-dependent protein deacetylase sirtuin 1 (SIRT1), which increases the expression of Parkin, leading to mitophagy activation