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I cannot emphasize enough- if youre on a GLP-1 RA, you need to be vigilant to eat adequate protein, to resistance train regularly, and to get good sleep

The clinical result is a medication that works through three complementary pathways simultaneously: Reduced appetite via GLP-1 and GIP receptor activation (eating less) Improved metabolic efficiency via GIP receptor activation on adipose tissue (storing fat less efficiently) Increased energy expenditure via glucagon receptor activation (burning more calories) This triple mechanism explains why retatrutides Phase 3 trial results exceed Mounjaros, which already uses two pathways

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In the penis, PDE5 breaks down a substance called cyclic guanosine monophosphate (cGMP)