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Grounds MD, Radley HG, Gebski BL, Bogoyevitch MA, Shavlakadze T

Among them, CHU-128 is a small molecule agonist from a series of compounds patented by Chugai (transferred to Eli Lilly in 2018)

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2is) have proven efficacy and safety in randomized clinical trials and observational real-life studies

An increase in AGE levels induces the production of receptor for advanced glycosylation end products (RAGE) and activates AGE-RAGE signaling (Sun et al., 2024)