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In line with previous reports in rats showing that peripherin is expressed in only 46% of DRG neurons 39 , we find expression of Gipr decreased by 43% in the DRG of Per-Cre + Gipr flx/flx mice ( Per-Gipr KO) relative to Per-Cre + Gipr wt/wt (WT) controls, and without differences in relative expression of Gipr in either the hypothalamus, hindbrain, sciatic nerve, epididymal white adipose tissue, pancreas, cerebellum, cerebral cortex, pituitary, kidney, duodenum, jejunum, ileum or colon (Extended Data Fig

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In clinical practice, patients losing significant weight with GLP-1 medications report variable effects on cellulite appearance