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PAR2 can also dampen inflammatory responses (56), and myeloid cellsynthesized FXa plays a pivotal role in PAR2-mediated immune suppression in the tumor microenvironment (30)

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PMCID: PMC10005804

With regard to the relationship between BDNF and depressive disorders, there is evidence that expression and activity of BDNF in the hippocampus are decreased in response to stress and increased by antidepressant treatment [40,41,42,43]