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For these reasons, the applicant believes that the Axoguard HA+ Nerve Protector TM meets the device category criterion

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The main adverse events reported on AIs (anastrozole, letrozole, and exemestane) were decreased libido (27%), arthralgia (24%), mood disorders (12.5%), asthenia (10%), headaches (6%), anxiety (4.5%), and palpitations (3%)

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