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Most of the mutants showed increased binding affinity, with S71pAcF and S26pAcF having the most significant improvements at 1.7 nM and 1.6 nM, representing a 9-fold increase compared to the wild type
Journal of Pharmacology and Experimental Therapeutics, 377(3), 417-440
The dorsal vagal complex (DVC) in the brainstem is where much of the appetite regulation occurs at a fundamental level
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