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[1] [17] For instance, in pivotal trials of semaglutide for diabetes, headache was reported by approximately 6-8% of participants receiving the medication compared to 5-6% in placebo groups, suggesting a modest but measurable association

Furthermore, a multinational cohort study involving five countries revealed that neither insulin detemir nor insulin glargine significantly increases cancer risk compared to human insulin [107]

These discrepancies may be due to different diagnostic criteria and evaluation methods used across studies [18]

8 If rapid and dramatic glycemic control on GLP-1RAs is the underlying mechanism of the association with DR, this phenomenon has already been described in the literature in association with insulin use