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doi: 10.1152/ajpgi.2000.279.5.G893 226

Most people begin noticing appetite suppression within 1 to 2 weeks, measurable weight loss within 2 to 4 weeks, and more significant results within 8 to 12 weeks

NICE guidance (NG28) recommends structured follow-up for patients on GLP-1 therapy, with specific continuation criteria that must be met to justify ongoing treatment

Freeze-thaw cycling can disrupt the copper coordination sphere as well as degrade the peptide backbones, so single-use aliquots are preferable to repeatedly accessing one stock