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This cytokine profile remodeling confers anti-inflammatory effects in several T cellmediated autoimmune disease models, including experimental autoimmune encephalomyelitis (EAE), collagen-induced arthritis, and imiquimod-induced psoriasiform dermatitis, supporting the clinical potential of Vitamin D as an immunomodulatory agent in skin disease therapy [166, 167]

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In a 2014 study published in the Journal of Pharmacology and Experimental Therapeutics , Benoist and colleagues used the HGF/c-Met dimerization antagonist Hinge to block Dihexas effects in scopolamine-impaired rats, demonstrating that the procognitive activity requires functional hepatocyte growth factor (HGF) / mesenchymal-epithelial transition factor (c-Met) receptor signaling [3]