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Common side effects include: Mild to Moderate Side Effects Nausea Vomiting Diarrhea or constipation Abdominal discomfort Appetite changes Headache Less Common Side Effects: Dizziness Fatigue Injection site reactions Temporary hypoglycemia when combined with other diabetes medications Rare but Serious Side Effects: Pancreatitis: Severe abdominal pain that may radiate to the back Gallbladder disease: Increased risk of gallstones Kidney issues: Worsening kidney function in some patients Thyroid tumors: Observed in animal studies, though human risk is unclear To minimize side effects, we recommend: Important Considerations Before Starting Semaglutide Medical History: Not recommended for individuals with a history of pancreatitis or thyroid cancer

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The severity depends partly on your geneticsspecific genetic variants in the GLP1R and GIPR pathways influence how sensitive your receptors are to the medication, which is why two people on the same dose experience vastly different side effect profiles