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Inhibition of TLGST with the metal chelating agent EDTA suggested it as a metalloenzyme

Seven more large-scale trials (the TRIUMPH program, over 5,800 people total) are still running and will release results throughout 2026

Shana E McCormack, Zi Wang, Kristin L Wade, Anna Dedio, Nicolette Cilenti, Julia Crowley, Franziska Plessow, Vaneeta Bamba, Jeffrey D Roizen, Yaoguang Jiang, Jack Stylli, Arjun Ramakrishnan, Michael L Platt, Karuna Shekdar, Michael J Fisher, Victoria L Vetter, Matthew Hocking, Rui Xiao, Elizabeth A Lawson, A Pilot Randomized Clinical Trial of Intranasal Oxytocin to Promote Weight Loss in Individuals With Hypothalamic Obesity, Journal of the Endocrine Society, Volume 7, Issue 5, May 2023, bvad037, 28

In this context, neutrophil infiltration can be stimulated by TNF- production 38