Vitamin C, in particular, is essential for the regeneration of glutathione
The considerable recovery of the dopaminergic neuronal clusters in the park flies ensued better negative geotactic behavior in the flies and prolonged their life span, suggesting improvement in motor coordination dysfunction associated with PD
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It is synthesised in the cytosol by glutamate-cysteine ligase (EC 6.3.2.2) and glutathione synthetase, with the first, rate-limiting step feedback-inhibited by glutathione itself and intracellular concentrations typically 1 to 8 mM (Griffith, Free Radical Biology and Medicine, 1999)