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The activated YAP translocates from the cytoplasm to the nucleus and forms a nuclear complex with P73, thereby inducing transcription of the pro-apoptotic puma gene (Matallanas et al., 2007)

Acknowledgements This work was supported by the National Natural Science Foundation of China (82073313 to D.L.), the joint project of the State Administration of Traditional Chinese Medicine and Health Commission of Shandong Province (GZY-KJS-SD-2023-094), the Traditional Chinese Medicine Special Project of Binzhou Medical University Affiliated Traditional Chinese Medicine Hospital (2023ZYZX02) and the 2023 Qilu Biancang Traditional Chinese Medicine Talent Cultivation Project (to D.L.)

This metabolite has a relatively long half-life of 2-3 weeks, making it an ideal indicator of overall vitamin D stores

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