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Studies have shown that the expression level of GPER in patients with T2D is closely related to their insulin sensitivity, with the downregulation of GPER expression being directly associated with the occurrence of insulin resistance [137]

Tirzepatide doses of 10 mg and 15 mg resulted in lower body weight reductions of 12.8% and 14.7% respectively in individuals with overweight or obesity and T2DM [121]

The global prevalence of MASLD increases in parallel with obesity rates, and a recent meta-analysis determined a prevalence of 75.27% in the obese population [5]

In this regard, race and time of conception revealed to be significantly important