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Given that the IR internalization is dependent on IR phosphorylation, the results above suggest that ITP might independently induce IR internalization, thereby exerting an allosteric targeting effect 19

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7a), whereas the simulated reaction for roGFP2(S 2 ) was by two orders of magnitude faster when GSH was already bound to PfGrx C88S (Fig

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10.1016/j.cell.2008.06.016 Cell 26 PatelN

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