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A 2022 review demonstrated that in plasma, increased cysteine can act as a pro-oxidant and trigger oxidative stress, positioning cysteine and related aminothiols as good markers of oxidative stress and useful tools in diagnosing and monitoring pathologic conditions such as CVD, obesity, and insulin resistance

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1 Gclc is expressed in non-epithelial cells, and its loss in tumors does cause redox or metabolic alterations

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