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This was together with the proposal that the function of this cycle was to protect redox-sensitive proteins from uncontrolled oxidation by reactive oxygen species (ROS), particularly hydrogen peroxide (H 2 O 2 )

As an effect of ROS on the central nervous system (CNS), which has a high lipid content and high oxygen consumption, the oxidative agents promote lipid peroxidation, leading to membrane fluid loss, suppressing membrane potential, and increasing the accumulation of ions, particularly Ca 2+

Early detection and treatment are key to preventing serious complications

Endotoxemia is associated with an adverse metabolic profile