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those can include: aging chronic disease poor nutrition and GI health exposure to high levels of certain pollutants or toxins chronic alcohol use ongoing stress of everyday life certain medications In some cases, you may benefit from supplementing with glutathione

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Generally, HO-1 levels remain low across diverse tissues except for the spleen, but diverse stimuli (like hydrogen peroxide, UV radiation, endotoxins, and hypoxia) can cause a strong inducible response for shielding cells from damaging oxidative and inflammatory agents [34]

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