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As described above, the role of charge-charge interactions is as important as 4.76% (2/42, supplementary file 4zgm.ic ) in the stabilization of the semaglutide backbone in complex with the extracellular domain (ECD) of GLP-1R (PDB ID: 4ZGM [29]), including only a few interfacial salt bridges (Table 1) and hydrogen bonds (Table 2)

SG was supported by a grant from the Department of Biotechnology, Government of India vide project no.: BT/PR7935/Med/14/1191/2006 which was sanctioned on 6 September, 2007

While clinical trials report gastrointestinal symptoms in 1544% of users, formally diagnosed gastroparesis appears uncommon

Baseline characteristics of the study group are shown in Table 1