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Clarke JM, Bird AR, Topping DL, Cobiac L
CYP2D6 The CYP2D6 enzyme is critically involved in the metabolism of approximately 20-25% of all developed drugs and more than 48 different clinical substrates (drugs) for this enzyme have been identified, which include -blockers, antidepressants, opioid analgesics, antiarrhythmics, and antipsychotics
DMN - dorsomedian
However, the finding that pretreatment of HL-60 human myeloid leukemia cells with buthionine sulfoxide, an inhibitor of glutathione biosynthesis, did not suppress the antineoplastic effect of JS-K suggests that mechanisms other than the glutathione-activated NO discharge contribute 8
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