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D-Nle-Tyr-Ile-NH (CH 2 )s-CONH 2 is more metabolically stable than Norleual, possesses an elongated half-life in the circulation and penetrates tissue effectively

In summary, in most animal modelsincluding NHPsvaccination or the administration of passive mAbs have demonstrated protection against challenge with SARS-CoV, MERS-CoV or SARS-CoV-2, although reports on SARS-CoV-2 are limited

The raw material itself presents several technical challenges in pharmacological evaluation and safety management

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