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S.McAvoyK.RichardJ.-P.et al

One of the most common modifications is hydroxylation catalysed by the cytochrome P-450-dependent mixed-function oxidase system

The precise mechanisms and protein mediators involved in this process remain incompletely understood

While erastin (an inhibitor of the cystineglutamate antiporter system Xc) was senolytic in SK-MEL-103 cells and BSO (a sulfoximine derivative that reduces levels of glutathione) in IMR90 cells, only the three GPX4 inhibitors tested showed senolytic activity in all senescent models tested (Extended Data Fig