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Of the seven cohort studies, five incur a combination of significant study design flaws due to prevalent user design (risk of depletion of susceptible bias), confounding by indication bias due to comparator that are used at different stages of diabetes severity, 19 unavailability of comprehensive capture of care data in patients longitudinal journey i.e

The standardized mean differences clearly favored tirzepatide across all treatment groups

Our study reinforces the efficacy of chronic semaglutide administration in mitigating anxiety-like and depressive behaviors in diabetic mice while revealing significant neurobiological changes in the cerebral cortex

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