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Cell Motil Cytoskelet 19:169179 Kenz A, Warnken T, Feige K et al (2018) Lower plasma trans-4-hydroxyproline and methionine sulfoxide levels are associated with insulin dysregulation in horses

Two experiments were conducted, a Dose-finding experiment involving 3 treatment weeks with the b S1 v S2 meal schedule, and the Meal schedule experiment involving 4 treatment weeks, one for each of the 4 meal schedule conditions

When purified protein was incubated with the gels (Figure 2), a significant decrease in GST-GFP was found in the solution after two hours compared to gel-free controls in the 1:1 (p = 0.008), 5:1 (p = 0.005), 20:1 (p = 0.02), 40:1 (p = 0.02), and 80:1 (p = 0.02) PEGDA to glutathione ratio gels (Figure 2A)

The post puts the incidence at twenty to forty percent of users, usually appearing within the first weeks of treatment