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The practical takeaway: Injection = high systemic distribution tendons, ligaments, muscle, joints, vascular tissue Oral = high local GI concentration intestinal lining, gastric mucosa, gut repair Nasal = intermediate systemic delivery potential neurological targeting, emerging evidence only Injectable BPC-157: Highest Bioavailability for Systemic and Musculoskeletal Goals Injectable BPC-157 is the best-studied delivery method for healing applications outside the gastrointestinal tract

and group 8: mice administered Dihexa [2]

781 Additionally, hepatocytes near the injury site upregulate Wnt/-catenin target genes and pericentral metabolic enzymes regulated by Wnt/-catenin, consistent with the regenerative effects promoted by Wnt2 and Wnt9b in pericentral endothelial cells