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Description

Britanin relieves ferroptosis-mediated myocardial ischaemia/reperfusion damage by upregulating GPX4 through activation of AMPK/GSK3/Nrf2 signalling

This suggests a requirement for osteocyte-derived IGF-1 in mediating normal growth plate development, potentially by stimulating chondrocyte maturation

Limitations of use: Not to be used in pregnancy, history of pancreatitis, Type 1 diabetes, personal or family history of medullary thyroid carcinoma, or multiple endocrine neoplasia type II Warnings & Precautions: Pancreatitis: Has been reported in clinical trials