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Titration escalates in 0.250.5 mg increments weekly or bi-weekly, with most therapeutic ranges reaching 2.03.0 mg based on individual tolerance and provider assessment

Common symptoms include: Dry, itchy skin Hair thinning or excessive hair shedding Fatigue and weakness Numbness or tingling in hands and feet Difficulty concentrating or brain fog If left unaddressed, a deficiency can lead to more serious issues, such as anemia or neurological complications

ROS and redox changes occur rapidly and frequently and impact function in an organ-specific manner

Soriano FX, Baxter P, Murray LM, Sporn MB, Gillingwater TH, Hardingham GE